| http://purl.uniprot.org/citations/25710909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25710909 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4(+) T cell subsets differentially support HIV-1 replication. For example, quiescent CD4(+) memory T cells are susceptible to HIV-1 infection but do not support robust HIV-1 transcription and have been implicated as the primary reservoir of latent HIV-1. T cell transcription factors that regulate maturation potentially limit HIV-1 transcription and mediate the establishment and maintenance of HIV-1 latency. We report that B lymphocyte-induced maturation protein-1 (Blimp-1), a critical regulator of B and T cell differentiation, is highly expressed in memory CD4(+) T cells compared with naive CD4(+) T cells and represses basal and Tat-mediated HIV-1 transcription. Blimp-1 binds an IFN-stimulated response element within HIV-1 provirus, and it is displaced following T cell activation. Reduction of Blimp-1 in infected primary T cells including CD4(+) memory T cells increases RNA polymerase II processivity, histone acetylation, and baseline HIV-1 transcription. Therefore, the transcriptional repressor, Blimp-1, is an intrinsic factor that predisposes CD4(+) memory T cells to latent HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1402581"xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/author | "Henderson A.J."xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/author | "Natarajan M."xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/author | "Alter G."xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/author | "Euler Z."xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/author | "Kaczmarek Michaels K."xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/author | "Viglianti G."xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/pages | "3267-3274"xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/title | "Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells."xsd:string |
| http://purl.uniprot.org/citations/25710909 | http://purl.uniprot.org/core/volume | "194"xsd:string |
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