| http://purl.uniprot.org/citations/25713055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25713055 | http://www.w3.org/2000/01/rdf-schema#comment | "The IL-6/signal transducer and activator of transcription 3 (STAT3) pathway is a critical signaling pathway for colitis-associated colorectal cancer (CAC). Peroxisome proliferator-activated receptor (PPAR)-δ, a lipid nuclear receptor, up-regulates IL-6. 15-Lipoxygenase-1 (15-LOX-1), which is crucial to production of lipid signaling mediators to terminate inflammation, down-regulates PPAR-δ. 15-LOX-1 effects on IL-6/STAT3 signaling and CAC tumorigenesis have not been determined. We report that intestinally targeted transgenic 15-LOX-1 expression in mice inhibited azoxymethane- and dextran sodium sulfate-induced CAC, IL-6 expression, STAT3 phosphorylation, and IL-6/STAT3 downstream target (Notch3 and MUC1) expression. 15-LOX-1 down-regulation was associated with IL-6 up-regulation in human colon cancer mucosa. Reexpression of 15-LOX-1 in human colon cancer cells suppressed IL-6 mRNA expression, STAT3 phosphorylation, IL-6 promoter activity, and PPAR-δ mRNA and protein expression. PPAR-δ overexpression in colonic epithelial cells promoted CAC tumorigenesis in mice and increased IL-6 expression and STAT3 phosphorylation, whereas concomitant 15-LOX-1 expression in colonic epithelial cells (15-LOX-1-PPAR-δ-Gut mice) suppressed these effects: the number of tumors per mouse (mean ± sem) was 4.22 ± 0.68 in wild-type littermates, 6.67 ± 0.83 in PPAR-δ-Gut mice (P = 0.026), and 2.25 ± 0.25 in 15-LOX-1-PPAR-δ-Gut mice (P = 0.0006). Identification of 15-LOX-1 suppression of PPAR-δ to inhibit IL-6/STAT3 signaling-driven CAC tumorigenesis provides mechanistic insights that can be used to molecularly target CAC."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.14-264515"xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Mao F."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Zuo X."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Li H.S."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Watowich S.S."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Elias E."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Moussalli M.J."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/author | "Shureiqi I."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/pages | "2359-2370"xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/title | "15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/25713055 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25713055 |
| http://purl.uniprot.org/citations/25713055 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25713055 |
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| http://purl.uniprot.org/uniprot/#_A2CF88-mappedCitation-25713055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25713055 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFG1-mappedCitation-25713055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25713055 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFT1-mappedCitation-25713055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25713055 |