| http://purl.uniprot.org/citations/25724647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25724647 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of neurons to maintain spine architecture and modulate it in response to synaptic activity is a crucial component of the cellular machinery that underlies information storage in pyramidal neurons of the hippocampus. Here we show a critical role for δ-catenin, a component of the cadherin-catenin cell adhesion complex, in regulating spine head width and length in pyramidal neurons of the hippocampus. The loss of Ctnnd2, the gene encoding δ-catenin, has been associated with the intellectual disability observed in the cri du chat syndrome, suggesting that the functional roles of δ-catenin are vital for neuronal integrity and higher order functions. We demonstrate that loss of δ-catenin in a mouse model or knockdown of δ-catenin in pyramidal neurons compromises spine head width and length, without altering spine dynamics. This is accompanied by a reduction in the levels of synaptic N-cadherin. The ability of δ-catenin to modulate spine architecture is critically dependent on its ability to interact with cadherin and PDZ domain-containing proteins. We propose that loss of δ-catenin during development perturbs synaptic architecture leading to developmental aberrations in neural circuit formation that contribute to the learning disabilities in a mouse model and humans with cri du chat syndrome."xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.632679"xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/author | "Yuan L."xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/author | "Seong E."xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/author | "Arikkath J."xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/author | "Beuscher J.L."xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/pages | "10947-10957"xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/title | "delta-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions."xsd:string |
| http://purl.uniprot.org/citations/25724647 | http://purl.uniprot.org/core/volume | "290"xsd:string |
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