| http://purl.uniprot.org/citations/25726529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25726529 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor p63 is a member of the p53 gene family that plays a complex role in cancer due to its involvement in epithelial differentiation, cell cycle arrest and apoptosis. MicroRNAs are a class of small, non-coding RNAs with an important regulatory role in various cellular processes, as well as in the development and progression of cancer. A number of microRNAs have been shown to function as transcriptional targets of p63. Conversely, microRNAs also can modulate the expression and activity of p63. However, the p63-microRNA regulatory circuit has not been addressed in depth so far. Here, computational genomic analysis was performed using miRtarBase, Targetscan, microRNA.ORG, DIANA-MICROT, RNA22-HSA and miRDB to analyze miRNA binding to the 3'UTR of p63. JASPAR (profile score threshold 80%) and TFSEARCH datasets were used to search transcriptional start sites for p53/p63 response elements. Remarkably, these data revealed 63 microRNAs that targeted p63. Furthermore, there were 39 microRNAs targeting p63 that were predicted to be regulated by p63. These analyses suggest a crosstalk between p63 and microRNAs. Here, we discuss the crosstalk between p63 and the microRNA network, and the role of their interactions in cancer."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.3020"xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Du J."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Hu G."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Gao K."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Zhang Y.'"xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Dai J."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/author | "Lv L."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/pages | "8434-8453"xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/title | "The microRNA feedback regulation of p63 in cancer progression."xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25726529 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25726529 |
| http://purl.uniprot.org/citations/25726529 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25726529 |
| http://purl.uniprot.org/uniprot/#_A0A141PNN3-mappedCitation-25726529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726529 |
| http://purl.uniprot.org/uniprot/#_A0A141PNN4-mappedCitation-25726529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726529 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4N5-mappedCitation-25726529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726529 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4N6-mappedCitation-25726529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726529 |