| http://purl.uniprot.org/citations/25726912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25726912 | http://www.w3.org/2000/01/rdf-schema#comment | "Apolipoprotein F (ApoF) inhibits cholesteryl ester transfer protein (CETP) activity and plays an important role in lipid metabolism. In the present study, the full-length human ApoF promoter was cloned, and the molecular mechanism of the regulation of ApoF was investigated. The ApoF promoter displayed higher activities in hepatoma cell lines, and the -198 nt to +79 nt promoter region contained the maximum promoter activity. In the promoter region of -198 nt to -2 nt there were four putative binding sites for transcription factors ETS-1/ETS-2 (named EBS-1 to EBS-4) and one for C/EBP. Mutation of EBS-2, EBS4 and the C/EBP binding site abolished the promoter activity, and ETS-1/ETS-2 and C/EBPα could interact with corresponding binding sites. In addition, overexpression of ETS-1/2 or C/EBPα enhanced, while dominant-negative mutants of ETS-1/2 and knockdown of C/EBPα decreased, ApoF promoter activities. ETS-1 and C/EBPα associated physically, and acted synergistically to activate ApoF transcription. These results demonstrated combined activation of the ApoF promoter by liver-enriched and ubiquitous transcription factors. Direct interactions between C/EBPα and ETS-1 were important for high liver-specific expression of ApoF."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biochi.2015.02.013"xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/author | "Wang D.P."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/author | "Zhang S.H."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/author | "Wu Y.L."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/author | "Xu S.H."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/author | "Shen X.B."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/author | "Chen W.N."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/name | "Biochimie"xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/pages | "1-9"xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/title | "Transcriptional regulation of the apolipoprotein F (ApoF) gene by ETS and C/EBPalpha in hepatoma cells."xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/25726912 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25726912 |
| http://purl.uniprot.org/citations/25726912 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25726912 |
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| http://purl.uniprot.org/uniprot/#_A8K725-mappedCitation-25726912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726912 |
| http://purl.uniprot.org/uniprot/#_B2RC09-mappedCitation-25726912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726912 |
| http://purl.uniprot.org/uniprot/#_B4DW78-mappedCitation-25726912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726912 |
| http://purl.uniprot.org/uniprot/#_P14921-mappedCitation-25726912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726912 |
| http://purl.uniprot.org/uniprot/#_P15036-mappedCitation-25726912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726912 |
| http://purl.uniprot.org/uniprot/#_P49715-mappedCitation-25726912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25726912 |