| http://purl.uniprot.org/citations/25733193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25733193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25733193 | http://www.w3.org/2000/01/rdf-schema#comment | "Borna disease virus (BDV) has a non-segmented, negative-stranded RNA genome and causes persistent infection in many animal species. Previous study has shown that the activation of the IκB kinase (IKK)/NF-κB pathway is reduced by BDV infection even in cells expressing constitutively active mutant IKK. This result suggests that BDV directly interferes with the IKK/NF-κB pathway. To elucidate the mechanism for the inhibition of NF-κB activation by BDV infection, we evaluated the cross-talk between BDV infection and the NF-κB pathway. Using Multiple EM for Motif Elicitation analysis, we found that the nucleoproteins of BDV (BDV-N) and NF-κB1 share a common ankyrin-like motif. When THP1-CD14 cells were pre-treated with the identified peptide, NF-κB activation by Toll-like receptor ligands was suppressed. The 20S proteasome assay showed that BDV-N and BDV-N-derived peptide inhibited the processing of NF-κB1 p105 into p50. Furthermore, immunoprecipitation assays showed that BDV-N interacted with NF-κB1 but not with NF-κB2, which shares no common motif with BDV-N. These results suggest BDV-N inhibits NF-κB1 processing by the 20S proteasome through its ankyrin-like peptide sequence, resulting in the suppression of IKK/NF-κB pathway activation. This inhibitory effect of BDV on the induction of the host innate immunity might provide benefits against persistent BDV infection."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep08696"xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep08696"xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Honda T."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Honda T."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Fujino K."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Fujino K."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Makino A."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Makino A."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Tomonaga K."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Tomonaga K."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Parrish N.F."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/author | "Parrish N.F."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/pages | "8696"xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/pages | "8696"xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/title | "Borna disease virus possesses an NF-kB inhibitory sequence in the nucleoprotein gene."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/title | "Borna disease virus possesses an NF-kB inhibitory sequence in the nucleoprotein gene."xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25733193 | http://purl.uniprot.org/core/volume | "5"xsd:string |