| http://purl.uniprot.org/citations/25733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25733582 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection and inflammation are invariably associated with activation of the blood coagulation mechanism, secondary to the inflammation-induced expression of the coagulation initiator tissue factor (TF) on innate immune cells. By investigating the role of cell-surface receptors for coagulation factors in mouse endotoxemia, we found that the protein C receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS)-regulated gene expression. In cultured bone marrow-derived myeloid cells and in monocytic RAW264.7 cells, the LPS-induced expression of functionally active TF, assembly of the ternary TF-VIIa-Xa initiation complex of blood coagulation, and the EPCR-dependent activation of protease-activated receptor 2 (PAR2) by the ternary TF-VIIa-Xa complex were required for the normal LPS induction of messenger RNAs encoding the TLR3/4 signaling adaptor protein Pellino-1 and the transcription factor interferon regulatory factor 8. In response to in vivo challenge with LPS, mice lacking EPCR or PAR2 failed to fully initiate an interferon-regulated gene expression program that included the Irf8 target genes Lif, Iigp1, Gbp2, Gbp3, and Gbp6. The inflammation-induced expression of TF and crosstalk with EPCR, PAR2, and TLR4 therefore appear necessary for the normal evolution of interferon-regulated host responses."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2014-11-610717"xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Jia S."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Weiler H."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Basu S."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Hernandez I."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Griffin J.H."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Zogg M."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Hessner M.J."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Liang H.P."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Kerschen E.J."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Ruf W."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/author | "Botros F."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/pages | "2845-2854"xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/title | "EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice."xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/25733582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25733582 |
| http://purl.uniprot.org/citations/25733582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25733582 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGS5-mappedCitation-25733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25733582 |
| http://purl.uniprot.org/uniprot/#_Q0VDX1-mappedCitation-25733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25733582 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J088-mappedCitation-25733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25733582 |
| http://purl.uniprot.org/uniprot/#_A2AUV5-mappedCitation-25733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25733582 |