| http://purl.uniprot.org/citations/25735981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25735981 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon binding of a Wnt ligand to the frizzled (FZD)-low density lipoprotein receptor related protein 5/6 (LRP5/6) receptor complex, the β-catenin destruction complex, composed of Axin1, adenomatous polyposis coli (APC), glycogen synthase kinase 3 (GSK3) and casein kinase 1 (CK1), is immediately inactivated, which causes β-catenin stabilization. However, the molecular mechanism of signal transduction from the receptor complex to the β-catenin destruction complex is controversial. Here we show that Wnt3a treatment promotes the dissociation of the Axin1-APC complex in glioblastoma cells cultured in serum-free medium. Experiments with the GSK3 inhibitor BIO suggest that Axin1-APC dissociation was controlled by phosphorylation. Introduction of a phosphomimetic mutation into Thr160 of Axin1, located in the APC-binding region RGS, abrogated the interaction of Axin1 with APC. Consistent with these observations, the Axin1 phosphomimetic mutant lost the ability to reduce β-catenin stability and to repress β-catenin/TCF-dependent transcription. Taken together, our results suggest a novel mechanism of Wnt signaling through the dissociation of the β-catenin destruction complex by Axin1 Thr160 modification."xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.02.118"xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/author | "Koyama-Nasu R."xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/author | "Nasu-Nishimura Y."xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/author | "Yamanaka R."xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/pages | "411-415"xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/title | "Thr160 of Axin1 is critical for the formation and function of the beta-catenin destruction complex."xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://purl.uniprot.org/core/volume | "459"xsd:string |
| http://purl.uniprot.org/citations/25735981 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25735981 |
| http://purl.uniprot.org/citations/25735981 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25735981 |
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| http://purl.uniprot.org/uniprot/#_A0A0S2Z4S3-mappedCitation-25735981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25735981 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4M1-mappedCitation-25735981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25735981 |
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