| http://purl.uniprot.org/citations/25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25736290 | http://www.w3.org/2000/01/rdf-schema#comment | "Formation of crossovers between homologous chromosomes during meiosis is positively regulated by the ZMM proteins (also known as SIC proteins). DNA damage checkpoint proteins also promote efficient formation of interhomolog crossovers. Here, we examined, in budding yeast, the meiotic role of the heterotrimeric DNA damage response clamp composed of Rad17, Ddc1 and Mec3 (known as '9-1-1' in other organisms) and a component of the clamp loader, Rad24 (known as Rad17 in other organisms). Cytological analysis indicated that the 9-1-1 clamp and its loader are not required for the chromosomal loading of RecA homologs Rad51 or Dmc1, but are necessary for the efficient loading of ZMM proteins. Interestingly, the loading of ZMM proteins onto meiotic chromosomes was independent of the checkpoint kinase Mec1 (the homolog of ATR) as well as Rad51. Furthermore, the ZMM member Zip3 (also known as Cst9) bound to the 9-1-1 complex in a cell-free system. These data suggest that, in addition to promoting interhomolog bias mediated by Rad51-Dmc1, the 9-1-1 clamp promotes crossover formation through a specific role in the assembly of ZMM proteins. Thus, the 9-1-1 complex functions to promote two crucial meiotic recombination processes, the regulation of interhomolog recombination and crossover formation mediated by ZMM."xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.161554"xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/author | "Shinohara M."xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/author | "Shinohara A."xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/author | "Bishop D.K."xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/author | "Hayashihara K."xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/author | "Grubb J.T."xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/pages | "1494-1506"xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/title | "DNA damage response clamp 9-1-1 promotes assembly of ZMM proteins for formation of crossovers and synaptonemal complex."xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/25736290 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25736290 |
| http://purl.uniprot.org/citations/25736290 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25736290 |
| http://purl.uniprot.org/uniprot/#_P38111-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_Q12175-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_P40511-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_P48581-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_Q02574-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_Q06032-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_Q08949-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_P25453-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_P31111-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |
| http://purl.uniprot.org/uniprot/#_P32641-mappedCitation-25736290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25736290 |