| http://purl.uniprot.org/citations/25737280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25737280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25737280 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular morphology is an essential determinant of cellular function in all kingdoms of life, yet little is known about how cell shape is controlled. Here we describe a molecular program that controls the early morphology of neurons through a metazoan-specific zinc finger protein, Unkempt. Depletion of Unkempt in mouse embryos disrupts the shape of migrating neurons, while ectopic expression confers neuronal-like morphology to cells of different nonneuronal lineages. We found that Unkempt is a sequence-specific RNA-binding protein and identified its precise binding sites within coding regions of mRNAs linked to protein metabolism and trafficking. RNA binding is required for Unkempt-induced remodeling of cellular shape and is directly coupled to a reduced production of the encoded proteins. These findings link post-transcriptional regulation of gene expression with cellular shape and have general implications for the development and disease of multicellular organisms."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.258483.115"xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.258483.115"xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Luscombe N.M."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Luscombe N.M."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Curk T."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Curk T."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Patel D.J."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Patel D.J."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Teplova M."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Teplova M."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Walsh C.A."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Walsh C.A."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Zuber J."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Zuber J."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Murphy E.A."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Murphy E.A."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Yang Y.J."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Yang Y.J."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |
| http://purl.uniprot.org/citations/25737280 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |