| http://purl.uniprot.org/citations/25737585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25737585 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytosolic Ca2+ signals, generated through the coordinated translocation of Ca2+ across the plasma membrane (PM) and endoplasmic reticulum (ER) membrane, mediate diverse cellular responses. Mitochondrial Ca2+ is important for mitochondrial function, and when cytosolic Ca2+ concentration becomes too high, mitochondria function as cellular Ca2+ sinks. By measuring mitochondrial Ca2+ currents, we found that mitochondrial Ca2+ uptake was reduced in chicken DT40 B lymphocytes lacking either the ER-localized inositol trisphosphate receptor (IP3R), which releases Ca2+ from the ER, or Orai1 or STIM1, components of the PM-localized Ca2+ -permeable channel complex that mediates store-operated calcium entry (SOCE) in response to depletion of ER Ca2+ stores. The abundance of MCU, the pore-forming subunit of the mitochondrial Ca2+ uniporter, was reduced in cells deficient in IP3R, STIM1, or Orai1. Chromatin immunoprecipitation and promoter reporter analyses revealed that the Ca2+ -regulated transcription factor CREB (cyclic adenosine monophosphate response element-binding protein) directly bound the MCU promoter and stimulated expression. Lymphocytes deficient in IP3R, STIM1, or Orai1 exhibited altered mitochondrial metabolism, indicating that Ca2+ released from the ER and SOCE-mediated signals modulates mitochondrial function. Thus, our results showed that a transcriptional regulatory circuit involving Ca2+ -dependent activation of CREB controls the Ca2+ uptake capability of mitochondria and hence regulates mitochondrial metabolism."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2005673"xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Baba Y."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Hoffman N.E."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Guo S."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Kurosaki T."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Rajan S."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Madesh M."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Kaufman B.A."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Hines K.J."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Jog N.R."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Shanmughapriya S."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Cheung J.Y."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Gill D.L."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Kolesar J.E."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Caricchio R."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/author | "Ragheb J."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/pages | "ra23"xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/title | "Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU."xsd:string |
| http://purl.uniprot.org/citations/25737585 | http://purl.uniprot.org/core/volume | "8"xsd:string |