| http://purl.uniprot.org/citations/25738462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25738462 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein synthesis is a major energy-consuming process, which is rapidly repressed upon energy stress by AMPK. How energy deficiency affects translation of mRNAs that cope with the stress response is poorly understood. We found that mitochondrial genes remain translationally active upon energy deprivation. Surprisingly, inhibition of translation is partially retained in AMPKα1/AMPKα2 knockout cells. Mitochondrial mRNAs are enriched with TISU, a translation initiator of short 5' UTR, which confers resistance specifically to energy stress. Purified 48S preinitiation complex is sufficient for initiation via TISU AUG, when preceded by a short 5' UTR. eIF1 stimulates TISU but inhibits non-TISU-directed initiation. Remarkably, eIF4GI shares this activity and also interacts with eIF1. Furthermore, eIF4F is released upon 48S formation on TISU. These findings describe a specialized translation tolerance mechanism enabling continuous translation of TISU genes under energy stress and reveal that a key step in start codon selection of short 5' UTR is eIF4F release."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2015.02.010"xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/author | "Viollet B."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/author | "Dikstein R."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/author | "Haimov O."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/author | "Svitkin Y."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/author | "Sinvani H."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/author | "Tamarkin-Ben-Harush A."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/pages | "479-492"xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/title | "Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection."xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/25738462 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25738462 |
| http://purl.uniprot.org/citations/25738462 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25738462 |
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| http://purl.uniprot.org/uniprot/#_B2RU10-mappedCitation-25738462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25738462 |
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| http://purl.uniprot.org/uniprot/#_Q4LE58-mappedCitation-25738462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25738462 |
| http://purl.uniprot.org/uniprot/#_Q04637-mappedCitation-25738462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25738462 |
| http://purl.uniprot.org/uniprot/#_O95065-mappedCitation-25738462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25738462 |