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http://purl.uniprot.org/citations/25741152http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25741152http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) patients, and explore its associations with patients' clinical parameters.

Methods

Fresh and paraffin-embedded tumor tissue samples from 60 PGI-DLBCL patients who had undergone surgery at the Tianjin Medical University Cancer Institute and Hospital from January 2005 to May 2010 were obtained, and 30 lymphoid tissue samples from reactive lymph nodes of age- and sex-matched patients represented control samples. Staging and diagnostic procedures were conducted according to the Lugano staging system. All patients had been treated with three therapeutic modalities: surgery, chemotherapy, or radiotherapy. Expression of MYC and BCL-2 were detected at both protein and mRNA levels by immunohistochemistry and real-time RT-PCR.

Results

Positive expression levels of MYC and BCL-2 proteins were detected in 35% and 45% of patients, respectively. MYC+/BCL-2+ protein was present in 30% of patients. MYC and BCL-2 protein levels were correlated with high MYC and BCL-2 mRNA expression, respectively (both P<0.05). We found that advanced-stage disease (at IIE-IV) was associated with MYC and BCL-2 coexpression levels (P<0.05). In addition, MYC+/BCL-2+ patients had more difficulty in achieving complete remission than others (P<0.05). Presence of MYC protein expression only affected overall survival and progression-free survival (PFS) when BCL-2 protein was coexpressed. The adverse prognostic impact of MYC+/BCL-2+ protein on PFS remained significant (P<0.05) even after adjusting for age, Lugano stage, international prognostic index, and BCL-2 protein expression in a multivariable model.

Conclusion

MYC+/BCL-2+ patients have worse chemotherapy response and poorer prognosis than patients who only express one of the two proteins, suggesting that assessment of MYC and BCL-2 expression by immunohistochemistry has clinical significance in predicting clinical outcomes of PGI-DLBCL patients."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.org/dc/terms/identifier"doi:10.3748/wjg.v21.i8.2433"xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Zhang L."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Zhang L.Y."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Zhao H.F."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Zhang Y.Z."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"You J."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Xia B."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Li X.W."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Guo S.Q."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Sun B.C."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/author"Qu F.L."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/pages"2433-2442"xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/title"Coexpression of MYC and BCL-2 predicts prognosis in primary gastrointestinal diffuse large B-cell lymphoma."xsd:string
http://purl.uniprot.org/citations/25741152http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/25741152http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25741152
http://purl.uniprot.org/citations/25741152http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25741152
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http://purl.uniprot.org/uniprot/#_P10415-mappedCitation-25741152http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25741152
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http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-25741152http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25741152
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