| http://purl.uniprot.org/citations/25743393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25743393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25743393 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms governing apical membrane assembly during biological tube development are poorly understood. Here, we show that extension of the C. elegans excretory canal requires cerebral cavernous malformation 3 (CCM-3), independent of the CCM1 orthologue KRI-1. Loss of ccm-3 causes canal truncations and aggregations of canaliculular vesicles, which form ectopic lumen (cysts). We show that CCM-3 localizes to the apical membrane, and in cooperation with GCK-1 and STRIPAK, promotes CDC-42 signalling, Golgi stability and endocytic recycling. We propose that endocytic recycling is mediated through the CDC-42-binding kinase MRCK-1, which interacts physically with CCM-3-STRIPAK. We further show canal membrane integrity to be dependent on the exocyst complex and the actin cytoskeleton. This work reveals novel in vivo roles of CCM-3·STRIPAK in regulating tube extension and membrane integrity through small GTPase signalling and vesicle dynamics, which may help explain the severity of CCM3 mutations in patients."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7449"xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7449"xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Derry W.B."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Derry W.B."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Gingras A.C."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Gingras A.C."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Goudreault M."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Goudreault M."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Xu P."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Xu P."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Yu B."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Yu B."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Wallace E."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Wallace E."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Chin K."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Chin K."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Knight J.D."xsd:string |
| http://purl.uniprot.org/citations/25743393 | http://purl.uniprot.org/core/author | "Knight J.D."xsd:string |