| http://purl.uniprot.org/citations/25744063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25744063 | http://www.w3.org/2000/01/rdf-schema#comment | "E3 ubiquitin ligase Cbl-b and c-Cbl play important roles in bone formation and maintenance. Cbl-b and c-Cbl regulate the activity of various receptor tyrosine kinases and intracellular protein tyrosine kinases mainly by regulating the degradation of target proteins. However, the precise mechanisms of how Cbl-b and c-Cbl regulate osteoblast differentiation are not well known. In this study, we investigated potential targets of Cbl-b and c-Cbl. We found that Cbl-b and c-Cbl inhibit BMP2-induced osteoblast differentiation in mesenchymal cells. Among various osteogenic transcription factors, we identified that Cbl-b and c-Cbl suppress the protein stability and transcriptional activity of Osterix. Our results suggest that Cbl-b and c-Cbl inhibit the function of Osterix by enhancing the ubiquitin-proteasome-mediated degradation of Osterix. Taken together, we propose novel regulatory roles of Cbl-b and c-Cbl during osteoblast differentiation in which Cbl-b and c-Cbl regulate the degradation of Osterix through the ubiquitin-proteasome pathway."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bone.2015.02.026"xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/author | "Choi Y.H."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/author | "Jin Y.H."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/author | "Lee K.Y."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/author | "Yeo C.Y."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/author | "Hur K.C."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/author | "Bahn M."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/name | "Bone"xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/pages | "201-209"xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/title | "Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix."xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/25744063 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25744063 |
| http://purl.uniprot.org/citations/25744063 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25744063 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP17-mappedCitation-25744063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25744063 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP47-mappedCitation-25744063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25744063 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP95-mappedCitation-25744063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25744063 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNF1-mappedCitation-25744063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25744063 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG61-mappedCitation-25744063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25744063 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RQ85-mappedCitation-25744063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25744063 |
| http://purl.uniprot.org/uniprot/#_B1NE42-mappedCitation-25744063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25744063 |