| http://purl.uniprot.org/citations/25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25751138 | http://www.w3.org/2000/01/rdf-schema#comment | "For proper chromosome segregation, sister kinetochores must interact with microtubules from opposite spindle poles (bi-orientation). To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B kinase (Ipl1 in budding yeast). Paradoxically, during this disruption, new attachments are still formed efficiently to enable fresh attempts at bi-orientation. How this is possible remains an enigma. Here we show that kinetochore attachment to the microtubule lattice (lateral attachment) is impervious to aurora B regulation, but attachment to the microtubule plus end (end-on attachment) is disrupted by this kinase. Thus, a new lateral attachment is formed without interference, then converted to end-on attachment and released if incorrect. This process continues until bi-orientation is established and stabilized by tension across sister kinetochores. We reveal how aurora B specifically promotes disruption of the end-on attachment through phospho-regulation of kinetochore components Dam1 and Ndc80. Our results reveal fundamental mechanisms for promoting error correction for bi-orientation."xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3128"xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/author | "Mino A."xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/author | "Kitamura E."xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/author | "Tanaka T.U."xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/author | "Novak B."xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/author | "Kalantzaki M."xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/pages | "421-433"xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/title | "Kinetochore-microtubule error correction is driven by differentially regulated interaction modes."xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/25751138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25751138 |
| http://purl.uniprot.org/citations/25751138 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25751138 |
| http://purl.uniprot.org/uniprot/#_P54199-mappedCitation-25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25751138 |
| http://purl.uniprot.org/uniprot/#_A0A8H4C045-mappedCitation-25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25751138 |
| http://purl.uniprot.org/uniprot/#_A0A8H4FAA4-mappedCitation-25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25751138 |
| http://purl.uniprot.org/uniprot/#_P38991-mappedCitation-25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25751138 |
| http://purl.uniprot.org/uniprot/#_P46675-mappedCitation-25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25751138 |
| http://purl.uniprot.org/uniprot/#_P09119-mappedCitation-25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25751138 |
| http://purl.uniprot.org/uniprot/#_P40460-mappedCitation-25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25751138 |
| http://purl.uniprot.org/uniprot/#_P53267-mappedCitation-25751138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25751138 |
| http://purl.uniprot.org/uniprot/P09119 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25751138 |