| http://purl.uniprot.org/citations/25753202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25753202 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) are a series of 18-25 nucleotides length non-coding RNAs, which play critical roles in tumorigenesis. Previous study has shown that microRNA-1274a (miR-1274a) is upregulated in human gastric cancer. However, its role in gastric cancer progression remains poorly understood. Therefore, the current study was aimed to examine the effect of miR-1274a on gastric cancer cells. We found that miR-1274a was overexpressed in gastric cancer tissues or gastric cancer cells including HGC27, MGC803, AGS, and SGC-7901 by qRT-PCR analysis. Transfection of miR-1274a markedly promoted gastric cancer cells proliferation and migration as well as induced epithelial-mesenchymal transition (EMT) of cancer cells. Our further examination identified FOXO4 as a target of miR-1274a, which did not influence FOXO4 mRNA expression but significantly inhibited FOXO4 protein expression. Moreover, miR-1274a overexpression activated PI3K/Akt signaling and upregulated cyclin D1, MMP-2 and MMP-9 expressions. With tumor xenografts in mice models, we also showed that miR-1274a promoted tumorigenesis of gastric cancer in vivo. In all, our study demonstrated that miR-1274a prompted gastric cancer cells growth and migration through dampening FOXO4 expression thus provided a potential target for human gastric cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.02.160"xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/author | "Zhang X.F."xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/author | "Liu G.H."xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/author | "Wang G.J."xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/author | "Ye Y.W."xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/pages | "629-635"xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/title | "The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4."xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://purl.uniprot.org/core/volume | "459"xsd:string |
| http://purl.uniprot.org/citations/25753202 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25753202 |
| http://purl.uniprot.org/citations/25753202 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25753202 |
| http://purl.uniprot.org/uniprot/#_B4DTB6-mappedCitation-25753202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25753202 |
| http://purl.uniprot.org/uniprot/#_P98177-mappedCitation-25753202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25753202 |
| http://purl.uniprot.org/uniprot/P98177 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25753202 |
| http://purl.uniprot.org/uniprot/B4DTB6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25753202 |