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http://purl.uniprot.org/citations/25755786http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25755786http://www.w3.org/2000/01/rdf-schema#comment"

Aims

To investigate the clinical significance of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in cervical cancer.

Methods

We examined ROR2 levels in 8 pairs of surgically resected cervical cancer and adjacent normal cervical tissues by real-time PCR. Moreover, we performed immunohistochemistry to examine ROR2 expression in 94 paraffin-embedded cervical cancer samples and analyzed the association between ROR2 expression, clinicopathologic factors and prognosis.

Results

ROR2 expression was up-regulated in cervical cancer tissues compared with adjacent normal cervix. In paraffin-embedded cervical cancer samples, high expression of ROR2 was shown in 40 (42.6%) of 94 cases, also, it was significantly associated with tumor stage (P = 0.018) and lymph nodes metastasis (P = 0.013). Moreover, survival analysis showed that ROR2 expression was an independent prognostic factor of poor overall and recurrent free survival (P = 0.045 and 0.001, respectively).

Conclusion

These results indicate that ROR2 is significantly correlated with cancer progression and poor prognosis in cervical cancer."xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/author"Jiang T."xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/author"Lin L."xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/author"Sun B."xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/author"Shen M."xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/author"Ye X."xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/name"Int J Clin Exp Pathol"xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/pages"856-861"xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/title"Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer."xsd:string
http://purl.uniprot.org/citations/25755786http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/25755786http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25755786
http://purl.uniprot.org/citations/25755786http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25755786
http://purl.uniprot.org/uniprot/#_A1L4F5-mappedCitation-25755786http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25755786
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http://purl.uniprot.org/uniprot/Q01974http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25755786
http://purl.uniprot.org/uniprot/A1L4F5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25755786