| http://purl.uniprot.org/citations/25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25758823 | http://www.w3.org/2000/01/rdf-schema#comment | "The spatial organization of the genome within the eukaryotic nucleus is a dynamic process that plays a central role in cellular processes such as gene expression, DNA replication, and chromosome segregation. Condensins are conserved multi-subunit protein complexes that contribute to chromosome organization by regulating chromosome compaction and homolog pairing. Previous work in our laboratory has shown that the Cap-H2 subunit of condensin II physically and genetically interacts with the Drosophila homolog of human MORF4-related gene on chromosome 15 (MRG15). Like Cap-H2, Mrg15 is required for interphase chromosome compaction and homolog pairing. However, the mechanism by which Mrg15 and Cap-H2 cooperate to maintain interphase chromatin organization remains unclear. Here, we show that Cap-H2 localizes to interband regions on polytene chromosomes and co-localizes with Mrg15 at regions of active transcription across the genome. We show that co-localization of Cap-H2 on polytene chromosomes is partially dependent on Mrg15. We have identified a binding motif within Cap-H2 that is essential for its interaction with Mrg15, and have found that mutation of this motif results in loss of localization of Cap-H2 on polytene chromosomes and results in partial suppression of Cap-H2-mediated compaction and homolog unpairing. Our data are consistent with a model in which Mrg15 acts as a loading factor to facilitate Cap-H2 binding to chromatin and mediate changes in chromatin organization."xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.org/dc/terms/identifier | "doi:10.1534/g3.115.016634"xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/author | "Kusch T."xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/author | "Bosco G."xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/author | "Rogers G.C."xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/author | "Wallace H.A."xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/author | "Klebba J.E."xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/name | "G3 (Bethesda)"xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/pages | "803-817"xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/title | "Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2."xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25758823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25758823 |
| http://purl.uniprot.org/citations/25758823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25758823 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHJ7-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHE3-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_Q8IGJ9-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_Q8IHA6-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_Q8INL2-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_Q9VMQ4-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_Q8MSN8-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_Q7YU87-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_Q8SY09-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |
| http://purl.uniprot.org/uniprot/#_Q9Y0I1-mappedCitation-25758823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25758823 |