| http://purl.uniprot.org/citations/25760325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25760325 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-β (TGF-β) strongly promotes renal tubulointerstitial fibrosis, but the cellular target that mediates its profibrotic actions has not been clearly identified. While in vitro data suggest that TGF-β-induced matrix production is mediated by renal fibroblasts, the role of these cells in TGF-β-dependent tubulointerstitial fibrosis following renal injury is not well defined. To address this, we deleted the TGF-β type II receptor in matrix-producing interstitial cells using two different inducible Cre models: COL1A2-Cre with a mesenchymal enhancer element and tenascin-Cre that targets medullary interstitial cells, and either the mouse unilateral ureteral obstruction or the aristolochic acid renal injury model. Renal interstitial cells lacking the TGF-β receptor had significantly impaired collagen I production, but, unexpectedly, overall tissue fibrosis was unchanged in the conditional knockouts after renal injury. Thus, abrogating TGF-β signaling in matrix-producing interstitial cells is not sufficient to reduce fibrosis after renal injury."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.org/dc/terms/identifier | "doi:10.1038/ki.2015.51"xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Zent R."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Reynolds K."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Harris R.C."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Gewin L."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Fogo A.B."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Hao C.M."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Alford C."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Neelisetty S."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Nlandu-Khodo S."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/author | "Woodbury L."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/name | "Kidney Int"xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/pages | "503-514"xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/title | "Renal fibrosis is not reduced by blocking transforming growth factor-beta signaling in matrix-producing interstitial cells."xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/25760325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25760325 |
| http://purl.uniprot.org/citations/25760325 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25760325 |
| http://purl.uniprot.org/uniprot/#_Q62312-mappedCitation-25760325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25760325 |
| http://purl.uniprot.org/uniprot/#_Q3UG22-mappedCitation-25760325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25760325 |
| http://purl.uniprot.org/uniprot/#_Q8BQS9-mappedCitation-25760325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25760325 |
| http://purl.uniprot.org/uniprot/#_Q80YX0-mappedCitation-25760325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25760325 |