| http://purl.uniprot.org/citations/25762865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25762865 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 6 (IL-6) is a major pro-inflammatory cytokine and dysregulation of IL-6 is relevant to many inflammatory diseases. Endotoxin induced tolerance of IL-6 is an important mechanism to avoid the excessive immune reaction. But to date, the molecular mechanisms of endotoxin tolerance of IL-6 remain unclear. Here we reported that IL-6 secretion and microRNA-181b (miR-181b) expression were inversely correlated following LPS stimulation. We also demonstrated that miR-181b targeting the 3'-UTR of IL-6 transcripts and up-regulation of miR-181b was associated with NF-kB. We further demonstrated that up-regulation of miR-181b in response to LPS was required for inducing IL-6 tolerance in macrophage. Our results suggested that the post-transcriptional control mediated by miR-181b could be involved in fine tuning the critical level of IL-6 expression in endotoxin tolerance."xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12950-015-0061-8"xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/author | "Chu M."xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/author | "Xie L."xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/name | "J Inflamm (Lond)"xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/pages | "18"xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/title | "MicroRNA-181b regulates endotoxin tolerance by targeting IL-6 in macrophage RAW264.7 cells."xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/25762865 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25762865 |
| http://purl.uniprot.org/citations/25762865 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25762865 |
| http://purl.uniprot.org/uniprot/Q04206#attribution-890C9C624987AF532CEC33F946902969 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25762865 |