| http://purl.uniprot.org/citations/25764978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25764978 | http://www.w3.org/2000/01/rdf-schema#comment | "Bax inhibitor-1 (BI-1) is an evolutionarily conserved pH-dependent Ca²⁺ leak channel in the endoplasmic reticulum and the founding member of a family of six highly hydrophobic mammalian proteins named transmembrane BAX inhibitor motif containing (TMBIM) 1-6 with BI-1 being TMBIM6. Here we compared the structure, subcellular localization, tissue expression and the effect on the cellular Ca²⁺ homeostasis of all family members side by side. We found that all TMBIM proteins possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 and its bacterial homologue BsYetJ. TMBIM1-3 and TMBIM4-6 represent two phylogenetically distinct groups that are localized in the Golgi apparatus (TMBIM1-3), endoplasmic reticulum (TMBIM4-6) or mitochondria (TMBIM5) but share a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic. TMBIM1 is mainly expressed in muscle, TMBIM2 and 3 in the nervous system, TMBIM4 and 5 are ubiquitously expressed and TMBIM6 in skeletal muscle, kidney, liver and spleen. All TMBIM proteins reduce the Ca²⁺ content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting Ca²⁺ concentration. These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca²⁺ homeostasis in a wide variety of tissues. This article is part of a Special Issue entitled: 13th European Symposium on Calcium."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2015.03.002"xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Schneider J."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Bultynck G."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Henke N."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Kiviluoto S."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Methner A."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Habicht J."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Schacht T."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Enders V."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/author | "Lisak D.A."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/pages | "2104-2114"xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/title | "The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA^2⁺-filling state."xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://purl.uniprot.org/core/volume | "1853"xsd:string |
| http://purl.uniprot.org/citations/25764978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25764978 |
| http://purl.uniprot.org/citations/25764978 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25764978 |
| http://purl.uniprot.org/uniprot/#_B3KSM0-mappedCitation-25764978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25764978 |
| http://purl.uniprot.org/uniprot/#_B4DFJ6-mappedCitation-25764978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25764978 |
| http://purl.uniprot.org/uniprot/#_B4DSV8-mappedCitation-25764978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25764978 |
| http://purl.uniprot.org/uniprot/#_B4DNL0-mappedCitation-25764978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25764978 |
| http://purl.uniprot.org/uniprot/#_B4DNZ1-mappedCitation-25764978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25764978 |
| http://purl.uniprot.org/uniprot/#_B4DUD2-mappedCitation-25764978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25764978 |