| http://purl.uniprot.org/citations/25771894 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25771894 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25771894 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigate how outgrowth at the basolateral cell membrane is coordinated with apical lumen formation in the development of a biological tube by characterizing exc-6, a gene required for C. elegans excretory cell (EC) tubulogenesis. We show that EXC-6 is orthologous to the human formin INF2, which polymerizes filamentous actin (F-actin) and binds microtubules (MTs) in vitro. Dominant INF2 mutations cause focal segmental glomerulosclerosis (FSGS), a kidney disease, and FSGS+Charcot-Marie-Tooth neuropathy. We show that activated INF2 can substitute for EXC-6 in C. elegans and that disease-associated mutations cause constitutive activity. Using genetic analysis and live imaging, we show that exc-6 regulates MT and F-actin accumulation at EC tips and dynamics of basolateral-localized MTs, indicating that EXC-6 organizes F-actin and MT cytoskeletons during tubulogenesis. The pathology associated with INF2 mutations is believed to reflect misregulation of F-actin, but our results suggest alternative or additional mechanisms via effects on MT dynamics."xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2015.01.009"xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2015.01.009"xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/author | "Greenwald I."xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/author | "Greenwald I."xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/author | "Shaye D.D."xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/author | "Shaye D.D."xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/pages | "743-755"xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/pages | "743-755"xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/title | "The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons."xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/title | "The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons."xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/25771894 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25771894 |
| http://purl.uniprot.org/citations/25771894 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25771894 |
| http://purl.uniprot.org/citations/25771894 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25771894 |
| http://purl.uniprot.org/citations/25771894 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25771894 |
| http://purl.uniprot.org/uniprot/Q9TYU9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/25771894 |
| http://purl.uniprot.org/uniprot/Q9TYU9#attribution-3DDB608F8E03FD87B6731082EF07B595 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25771894 |