| http://purl.uniprot.org/citations/25772760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25772760 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self-renewal and circulating tumor cell (CTC) capacities were mechanistically explored. TM4SF5-dependent sphere growth was correlated with CD133+, CD24-, ALDH activity, and a physical association between CD44 and TM4SF5. The TM4SF5/CD44 interaction activated c-Src/STAT3/Twist1/B mi1 signaling for spheroid formation, while disturbing the interaction, expression, or activity of any component in this signaling pathway inhibited spheroid formation. In serial xenografts of less than 5,000 cells/injection, TM4SF5-positive tumors exhibited locally-increased CD44 expression, suggesting tumor cell differentiation. TM4SF5-positive cells were identified circulating in blood 4 to 6 weeks after orthotopic liver-injection. Anti-TM4SF reagents blocked their metastasis to distal intestinal organs. Altogether, our results provide evidence that TM4SF5 promotes self-renewal and CTC properties supported by CD133+/TM4SF5+/CD44+(TM4SF5-bound)/ALDH+/CD24-markers during HCC metastasis."xsd:string |
| http://purl.uniprot.org/citations/25772760 | http://purl.org/dc/terms/identifier | "doi:10.5483/bmbrep.2015.48.3.047"xsd:string |
| http://purl.uniprot.org/citations/25772760 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/25772760 | http://purl.uniprot.org/core/author | "Lee J.W."xsd:string |
| http://purl.uniprot.org/citations/25772760 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25772760 | http://purl.uniprot.org/core/name | "BMB Rep"xsd:string |
| http://purl.uniprot.org/citations/25772760 | http://purl.uniprot.org/core/pages | "127-128"xsd:string |
| http://purl.uniprot.org/citations/25772760 | http://purl.uniprot.org/core/title | "Self-renewal and circulating capacities of metastatic hepatocarcinoma cells required for collaboration between TM4SF5 and CD44."xsd:string |
| http://purl.uniprot.org/citations/25772760 | http://purl.uniprot.org/core/volume | "48"xsd:string |
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