| http://purl.uniprot.org/citations/25774501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25774501 | http://www.w3.org/2000/01/rdf-schema#comment | "Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies in Western societies. IUGR is a strong predictor of reduced short-term neonatal survival and impairs long-term health in children. Placental insufficiency is often associated with IUGR; however, the molecular mechanisms involved in the pathogenesis of placental insufficiency and IUGR are largely unknown. Here, we developed a mouse model of fetal-growth restriction and placental insufficiency that is induced by a midgestational stress challenge. Compared with control animals, pregnant dams subjected to gestational stress exhibited reduced progesterone levels and placental heme oxygenase 1 (Hmox1) expression and increased methylation at distinct regions of the placental Hmox1 promoter. These stress-triggered changes were accompanied by an altered CD8+ T cell response, as evidenced by a reduction of tolerogenic CD8+CD122+ T cells and an increase of cytotoxic CD8+ T cells. Using progesterone receptor- or Hmox1-deficient mice, we identified progesterone as an upstream modulator of placental Hmox1 expression. Supplementation of progesterone or depletion of CD8+ T cells revealed that progesterone suppresses CD8+ T cell cytotoxicity, whereas the generation of CD8+CD122+ T cells is supported by Hmox1 and ameliorates fetal-growth restriction in Hmox1 deficiency. These observations in mice could promote the identification of pregnancies at risk for IUGR and the generation of clinical interventional strategies."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci68140"xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Karimi K."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Plosch T."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Ho H."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Sass G."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Berger R.G."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Lydon J.P."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Barikbin R."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Horst A.K."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "DeMayo F.J."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Parker V.J."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Arck P.C."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Hecher K."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Solano M.E."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Jago C."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Kowal M.K."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Modest K."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "O'Rourke G.E."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/author | "Remus C.C."xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/pages | "1726-1738"xsd:string |
| http://purl.uniprot.org/citations/25774501 | http://purl.uniprot.org/core/title | "Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation."xsd:string |