| http://purl.uniprot.org/citations/25774694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25774694 | http://www.w3.org/2000/01/rdf-schema#comment | "Persistent activation of NF-κB by the Human T-cell leukemia virus type 1 (HTLV-1) oncoprotein, Tax, is vital for the development and pathogenesis of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). K63-linked polyubiquitinated Tax activates the IKK complex in the plasma membrane-associated lipid raft microdomain. Tax also interacts with TAX1BP1 to inactivate the NF-κB negative regulatory ubiquitin-editing A20 enzyme complex. However, the molecular mechanisms of Tax-mediated IKK activation and A20 protein complex inactivation are poorly understood. Here, we demonstrated that membrane associated CADM1 (Cell adhesion molecule1) recruits Ubc13 to Tax, causing K63-linked polyubiquitination of Tax, and IKK complex activation in the membrane lipid raft. The c-terminal cytoplasmic tail containing PDZ binding motif of CADM1 is critical for Tax to maintain persistent NF-κB activation. Finally, Tax failed to inactivate the NF-κB negative regulator ubiquitin-editing enzyme A20 complex, and activate the IKK complex in the lipid raft in absence of CADM1. Our results thus indicate that CADM1 functions as a critical scaffold molecule for Tax and Ubc13 to form a cellular complex with NEMO, TAX1BP1 and NRP, to activate the IKK complex in the plasma membrane-associated lipid rafts, to inactivate NF-κB negative regulators, and maintain persistent NF-κB activation in HTLV-1 infected cells."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1004721"xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Thomas R."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Rauch D."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Ratner L."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "van der Weyden L."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Nyborg J.K."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Hunte R."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Ramos J.C."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Shembade N."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/author | "Pujari R."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/pages | "e1004721"xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/title | "Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-kappaB inhibitor A20 and constitutive NF-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/25774694 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25774694 |
| http://purl.uniprot.org/citations/25774694 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25774694 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS08-mappedCitation-25774694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25774694 |
| http://purl.uniprot.org/uniprot/#_E0CY16-mappedCitation-25774694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25774694 |
| http://purl.uniprot.org/uniprot/#_A0A4Z1-mappedCitation-25774694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25774694 |
| http://purl.uniprot.org/uniprot/#_A0A668KLV1-mappedCitation-25774694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25774694 |
| http://purl.uniprot.org/uniprot/#_B5L830-mappedCitation-25774694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25774694 |