| http://purl.uniprot.org/citations/25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25779634 | http://www.w3.org/2000/01/rdf-schema#comment | "Vertebrate immunity has evolved a modular architecture in response to perturbations. Allergic inflammation represents such a module, with signature features of antigen-specific IgE and tissue eosinophilia, although the cellular and molecular circuitry coupling these responses remains unclear. Here, we use genetic and imaging approaches in models of IgE-dependent eosinophilic dermatitis to demonstrate a requisite role for basophils. After antigenic inflammation, basophils initiate transmigration like other granulocytes but, upon activation via their high-affinity IgE receptor, alter their migratory kinetics to persist at the endothelium. Prolonged basophil-endothelial interactions, in part dependent on activation of focal adhesion kinases, promote delivery of basophil-derived IL-4 to the endothelium and subsequent induction of endothelial vascular cell adhesion molecule-1 (VCAM-1), which is required for eosinophil accumulation. Thus, basophils are gatekeepers that link adaptive immunity with innate effector programs by altering access to tissue sites by activation-induced interactions with the endothelium."xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20141671"xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/author | "Locksley R.M."xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/author | "Sullivan B.M."xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/author | "Allen C.D."xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/author | "Cheng L.E."xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/author | "Liang H.E."xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/author | "Retana L.E."xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/pages | "513-524"xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/title | "IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function."xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://purl.uniprot.org/core/volume | "212"xsd:string |
| http://purl.uniprot.org/citations/25779634 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25779634 |
| http://purl.uniprot.org/citations/25779634 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25779634 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXC5-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |
| http://purl.uniprot.org/uniprot/#_E9QA93-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |
| http://purl.uniprot.org/uniprot/#_A0A286YDN6-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW45-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |
| http://purl.uniprot.org/uniprot/#_E9Q6H6-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |
| http://purl.uniprot.org/uniprot/#_A7VJD3-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |
| http://purl.uniprot.org/uniprot/#_P48999-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |
| http://purl.uniprot.org/uniprot/#_G3UXB0-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |
| http://purl.uniprot.org/uniprot/#_P07750-mappedCitation-25779634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25779634 |