| http://purl.uniprot.org/citations/25785643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25785643 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin-dependent kinase 5 (Cdk5) is a unique member of a family of serine/threonine cyclin-dependent protein kinases. We previously demonstrated disruption of Cdk5 gene expression in mice impairs T-cell function and ameliorates T-cell-mediated neuroinflammation. Here, we show Cdk5 modulates gene expression during T-cell activation by impairing the repression of gene transcription by histone deacetylase 1 (HDAC1) through specific phosphorylation of the mSin3a protein at serine residue 861. Disruption of Cdk5 activity in T-cells enhances HDAC activity and binding of the HDAC1/mSin3a complex to the IL-2 promoter, leading to suppression of IL-2 gene expression. These data point to essential roles for Cdk5 in regulating gene expression in T-cells and transcriptional regulation by the co-repressor mSin3a."xsd:string |
| http://purl.uniprot.org/citations/25785643 | http://purl.org/dc/terms/identifier | "doi:10.4161/15384101.2014.987621"xsd:string |
| http://purl.uniprot.org/citations/25785643 | http://purl.uniprot.org/core/author | "Lam E."xsd:string |
| http://purl.uniprot.org/citations/25785643 | http://purl.uniprot.org/core/author | "Letterio J.J."xsd:string |
| http://purl.uniprot.org/citations/25785643 | http://purl.uniprot.org/core/author | "Pareek T.K."xsd:string |
| http://purl.uniprot.org/citations/25785643 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25785643 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/25785643 | http://purl.uniprot.org/core/pages | "1327-1336"xsd:string |
| http://purl.uniprot.org/citations/25785643 | http://purl.uniprot.org/core/title | "Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex."xsd:string |
| http://purl.uniprot.org/citations/25785643 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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