| http://purl.uniprot.org/citations/25790376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25790376 | http://www.w3.org/2000/01/rdf-schema#comment | "Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson's disease (PD). The formation of α-syn aggregates results from aberrant accumulation of misfolded α-syn and insufficient or impaired activity of the two main intracellular protein degradation systems, namely the ubiquitin-proteasome system and the autophagy-lysosomal pathway. In this study, we investigated the role of transcription factor EB (TFEB), a master regulator of the autophagy-lysosomal pathway, in preventing the accumulation of α-syn aggregates in human neuroglioma cells. We found that TFEB overexpression reduces the accumulation of aggregated α-syn by inducing autophagic clearance of α-syn. Furthermore, we showed that pharmacological activation of TFEB using 2-hydroxypropyl-β-cyclodextrin promotes autophagic clearance of aggregated α-syn. In summary, our findings demonstrate that TFEB modulates autophagic clearance of α-syn and suggest that pharmacological activation of TFEB is a promising strategy to enhance the degradation of α-syn aggregates."xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0120819"xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/author | "Zeng Y."xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/author | "Segatori L."xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/author | "Kilpatrick K."xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/author | "Hancock T."xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/pages | "e0120819"xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/title | "Genetic and chemical activation of TFEB mediates clearance of aggregated alpha-synuclein."xsd:string |
| http://purl.uniprot.org/citations/25790376 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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