| http://purl.uniprot.org/citations/25790768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25790768 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell immunoglobulin and mucin domain protein (TIM)-3 can function as a modulator that links inflammation and subsequent brain damage after ischaemia. We find that TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes, brain resident immune cells, in a hypoxia-inducible factor (HIF)-1-dependent manner. Notably, blockade of TIM-3 markedly reduces infarct size, neuronal cell death, oedema formation and neutrophil infiltration in H/I mice. Hypoxia-triggered neutrophil migration and infarction are also decreased in HIF-1α-deficient mice. Moreover, functional neurological deficits after H/I are significantly improved in both anti-TIM-3-treated mice and myeloid-specific HIF-1α-deficient mice. Further understanding of these insights could serve as the basis for broadening the therapeutic scope against hypoxia-associated brain diseases."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7340"xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Yoon H.J."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Johnson R.S."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Park E.J."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Chang C.Y."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Ahn Y.H."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Kim I.H."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Koh H.S."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Jeon S.B."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/author | "Jeon S.H."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/pages | "6340"xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/title | "The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia."xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25790768 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25790768 |
| http://purl.uniprot.org/citations/25790768 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25790768 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-25790768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25790768 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-25790768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25790768 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-25790768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25790768 |
| http://purl.uniprot.org/uniprot/#_D3Z3I4-mappedCitation-25790768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25790768 |
| http://purl.uniprot.org/uniprot/#_P08905-mappedCitation-25790768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25790768 |