| http://purl.uniprot.org/citations/25790857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25790857 | http://www.w3.org/2000/01/rdf-schema#comment | "Across phyla, reduced nicotinamide adenine dinucleotide phosphate (NADPH) transfers intracellular reducing power to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR), thereby supporting fundamental housekeeping and antioxidant pathways. Here we show that a third, NADPH-independent pathway can bypass the need for TrxR1 and GR in mammalian liver. Most mice genetically engineered to lack both TrxR1 and GR in all hepatocytes ('TR/GR-null livers') remain long-term viable. TR/GR-null livers cannot reduce oxidized glutathione disulfide using NADPH but still require continuous glutathione synthesis. Inhibition of cystathionine γ-lyase causes rapid necrosis of TR/GR-null livers, indicating that methionine-fueled trans-sulfuration supplies the necessary cysteine precursor for glutathione synthesis via an NADPH-independent pathway. We further show that dietary methionine provides the cytosolic disulfide-reducing power and all sulfur amino acids in TR/GR-null livers. Although NADPH is generally considered an essential reducing currency, these results indicate that hepatocytes can adequately sustain cytosolic redox homeostasis pathways using either NADPH or methionine."xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7479"xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/author | "Eriksson S."xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/author | "Schmidt E.E."xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/author | "Prigge J.R."xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/author | "Arner E.S."xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/author | "Talago E.A."xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/pages | "6479"xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/title | "Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver."xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25790857 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25790857 |
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| http://purl.uniprot.org/uniprot/#_A0A1W2P6U1-mappedCitation-25790857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25790857 |
| http://purl.uniprot.org/uniprot/#_K7R066-mappedCitation-25790857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25790857 |
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