| http://purl.uniprot.org/citations/25795300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25795300 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclic stretch is an artificial model of mechanical force loading, which induces the reorientation of vascular endothelial cells and their stress fibers in a direction perpendicular to the stretch axis. Rho family GTPases are crucial for cyclic-stretch-induced endothelial cell reorientation; however, the mechanism underlying stretch-induced activation of Rho family GTPases is unknown. A screen of short hairpin RNAs targeting 63 Rho guanine nucleotide exchange factors (Rho-GEFs) revealed that at least 11 Rho-GEFs – Abr, alsin, ARHGEF10, Bcr, GEF-H1 (also known as ARHGEF2), LARG (also known as ARHGEF12), p190RhoGEF (also known as ARHGEF28), PLEKHG1, P-REX2, Solo (also known as ARHGEF40) and α-PIX (also known as ARHGEF6) – which specifically or broadly target RhoA, Rac1 and/or Cdc42, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells. Overexpression of Solo induced RhoA activation and F-actin accumulation at cell-cell and cell-substrate adhesion sites. Knockdown of Solo suppressed cyclic-stretch- or tensile-force-induced RhoA activation. Moreover, knockdown of Solo significantly reduced cyclic-stretch-induced perpendicular reorientation of endothelial cells when cells were cultured at high density, but not when they were cultured at low density or pretreated with EGTA or VE-cadherin-targeting small interfering RNAs. These results suggest that Solo is involved in cell-cell-adhesion-mediated mechanical signal transduction during cyclic-stretch-induced endothelial cell reorientation."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.157503"xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/author | "Fujiwara S."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/author | "Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/author | "Sato M."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/author | "Sakamoto N."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/author | "Mashiko T."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/author | "Abiko H."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/author | "Hiatari R."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/pages | "1683-1695"xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/title | "Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/25795300 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25795300 |
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