| http://purl.uniprot.org/citations/25795664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25795664 | http://www.w3.org/2000/01/rdf-schema#comment | "Brc1, which was first identified as a high-copy, allele-specific suppressor of a mutation impairing the Smc5-Smc6 holocomplex in Schizosaccharomyces pombe, protects genome integrity during normal DNA replication and when cells are exposed to toxic compounds that stall or collapse replication forks. The C-terminal tandem BRCT (BRCA1 C-terminus) domain of fission yeast Brc1 docks with phosphorylated histone H2A (γH2A)-marked chromatin formed by ATR/Rad3 checkpoint kinase at arrested and damaged replication forks; however, how Brc1 functions in relation to other genome protection modules remains unclear. Here, an epistatic mini-array profile reveals critical requirements for Brc1 in mutants that are defective in multiple DNA damage response pathways, including checkpoint signaling by Rad3-Rad26/ATR-ATRIP kinase, DNA repair by Smc5-Smc6 holocomplex, replication fork stabilization by Mrc1/claspin and Swi1-Swi3/Timeless-Tipin, and control of ubiquitin-regulated proteolysis by the COP9 signalosome (CSN). Exogenous genotoxins enhance these negative genetic interactions. Rad52 and RPA foci are increased in CSN-defective cells, and loss of γH2A increases genotoxin sensitivity, indicating a critical role for the γH2A-Brc1 module in stabilizing replication forks in CSN-defective cells. A negative genetic interaction with the Nse6 subunit of Smc5-Smc6 holocomplex indicates that the DNA repair functions of Brc1 and Smc5-Smc6 holocomplex are at least partially independent. Rtt107, the Brc1 homolog in Saccharomyces cerevisiae, has a very different pattern of genetic interactions, indicating evolutionary divergence of functions and DNA damage responses."xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.org/dc/terms/identifier | "doi:10.1534/g3.115.017251"xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/author | "Krogan N.J."xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/author | "Sanchez A."xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/author | "Russell P."xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/author | "Roguev A."xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/name | "G3 (Bethesda)"xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/pages | "953-962"xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/title | "Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants."xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25795664 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25795664 |
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| http://purl.uniprot.org/uniprot/#_P50531-mappedCitation-25795664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25795664 |
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