| http://purl.uniprot.org/citations/25799984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25799984 | http://www.w3.org/2000/01/rdf-schema#comment | "The structure of messenger RNA is important for post-transcriptional regulation, mainly because it affects binding of trans-acting factors. However, little is known about the in vivo structure of full-length mRNAs. Here we present hiCLIP, a biochemical technique for transcriptome-wide identification of RNA secondary structures interacting with RNA-binding proteins (RBPs). Using this technique to investigate RNA structures bound by Staufen 1 (STAU1) in human cells, we uncover a dominance of intra-molecular RNA duplexes, a depletion of duplexes from coding regions of highly translated mRNAs, an unexpected prevalence of long-range duplexes in 3' untranslated regions (UTRs), and a decreased incidence of single nucleotide polymorphisms in duplex-forming regions. We also discover a duplex spanning 858 nucleotides in the 3' UTR of the X-box binding protein 1 (XBP1) mRNA that regulates its cytoplasmic splicing and stability. Our study reveals the fundamental role of mRNA secondary structures in gene expression and introduces hiCLIP as a widely applicable method for discovering new, especially long-range, RNA duplexes."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature14280"xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/author | "Luscombe N.M."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/author | "Sugimoto Y."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/author | "D'Ambrogio A."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/author | "Militti C."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/author | "Darbo E."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/author | "Vigilante A."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/author | "Zirra A."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/pages | "491-494"xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/title | "hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1."xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://purl.uniprot.org/core/volume | "519"xsd:string |
| http://purl.uniprot.org/citations/25799984 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25799984 |
| http://purl.uniprot.org/citations/25799984 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25799984 |
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| http://purl.uniprot.org/uniprot/#_A8K622-mappedCitation-25799984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25799984 |
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