| http://purl.uniprot.org/citations/25799994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25799994 | http://www.w3.org/2000/01/rdf-schema#comment | "Adult stem cells occur in niches that balance self-renewal with lineage selection and progression during tissue homeostasis. Following injury, culture or transplantation, stem cells outside their niche often display fate flexibility. Here we show that super-enhancers underlie the identity, lineage commitment and plasticity of adult stem cells in vivo. Using hair follicle as a model, we map the global chromatin domains of hair follicle stem cells and their committed progenitors in their native microenvironments. We show that super-enhancers and their dense clusters ('epicentres') of transcription factor binding sites undergo remodelling upon lineage progression. New fate is acquired by decommissioning old and establishing new super-enhancers and/or epicentres, an auto-regulatory process that abates one master regulator subset while enhancing another. We further show that when outside their niche, either in vitro or in wound-repair, hair follicle stem cells dynamically remodel super-enhancers in response to changes in their microenvironment. Intriguingly, some key super-enhancers shift epicentres, enabling their genes to remain active and maintain a transitional state in an ever-changing transcriptional landscape. Finally, we identify SOX9 as a crucial chromatin rheostat of hair follicle stem cell super-enhancers, and provide functional evidence that super-enhancers are dynamic, dense transcription-factor-binding platforms which are acutely sensitive to pioneer master regulators whose levels define not only spatial and temporal features of lineage-status but also stemness, plasticity in transitional states and differentiation."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature14289"xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Fuchs E."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Nikolova M."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Oristian D.S."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Rockowitz S."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Polak L."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Asare A."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Kadaja M."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Larsen S.B."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/author | "Adam R.C."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/pages | "366-370"xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/title | "Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice."xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://purl.uniprot.org/core/volume | "521"xsd:string |
| http://purl.uniprot.org/citations/25799994 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25799994 |
| http://purl.uniprot.org/citations/25799994 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25799994 |
| http://purl.uniprot.org/uniprot/#_B1AQ78-mappedCitation-25799994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25799994 |
| http://purl.uniprot.org/uniprot/#_C7B5P0-mappedCitation-25799994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25799994 |
| http://purl.uniprot.org/uniprot/#_C7B5P1-mappedCitation-25799994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25799994 |
| http://purl.uniprot.org/uniprot/#_C7B5P2-mappedCitation-25799994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25799994 |