| http://purl.uniprot.org/citations/25801429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25801429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25801429 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling lymphocyte activation molecules (SLAMs) play an integral role in immune regulation. Polymorphisms in the SLAM family receptors are implicated in human and mouse model of lupus disease. The lupus-associated, somatically mutated, and class-switched pathogenic autoantibodies are generated in spontaneously developed germinal centers (GCs) in secondary lymphoid organs. The role and mechanism of B cell-intrinsic expression of polymorphic SLAM receptors that affect B cell tolerance at the GC checkpoint are not clear. In this study, we generated several bacterial artificial chromosome-transgenic mice that overexpress C57BL/6 (B6) alleles of different SLAM family genes on an autoimmune-prone B6.Sle1b background. B6.Sle1b mice overexpressing B6-derived Ly108 and CD84 exhibit a significant reduction in the spontaneously developed GC response and autoantibody production compared with B6.Sle1b mice. These data suggest a prominent role for Sle1b-derived Ly108 and CD84 in altering the GC checkpoint. We further confirm that expression of lupus-associated CD84 and Ly108 specifically on GC B cells in B6.Sle1b mice is sufficient to break B cell tolerance, leading to an increase in autoantibody production. In addition, we observe that B6.Sle1b B cells have reduced BCR signaling and a lower frequency of B cell-T cell conjugates; the reverse is seen in B6.Sle1b mice overexpressing B6 alleles of CD84 and Ly108. Finally, we find a significant decrease in apoptotic GC B cells in B6.Sle1b mice compared with B6 controls. Our study establishes a central role for GC B cell-specific CD84 and Ly108 expression in maintaining B cell tolerance in GCs and in preventing autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1403023"xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1403023"xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Limaye N."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Limaye N."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Wakeland E.K."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Wakeland E.K."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Abraham T."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Abraham T."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Khan T.N."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Khan T.N."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Chan A.Y."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Chan A.Y."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Chodisetti S.B."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Chodisetti S.B."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Domeier P.P."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Domeier P.P."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Elias M.J."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Elias M.J."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Rahman Z.S."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Rahman Z.S."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Shwetank V."xsd:string |
| http://purl.uniprot.org/citations/25801429 | http://purl.uniprot.org/core/author | "Shwetank V."xsd:string |