DESCRIBE <http://purl.uniprot.org/citations/25802082>

Subject	Predicate	Object
http://purl.uniprot.org/citations/25802082	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25802082	http://www.w3.org/2000/01/rdf-schema#comment	" Background 5-Lipoxygenase (5-LO) is a protein widely distributed in the central nervous system where it modulates amyloidosis and memory impairments in transgenic mouse models of Alzheimer's disease. However, no data are available as to whether 5-LO is elevated in human tauopathy or if it directly influences tau pathology in a relevant model of the disease. Methods We assayed 5-LO levels in brain samples from patients with tauopathy and transgenic tau mice, and we evaluated the effect of 5-LO pharmacologic inhibition on the phenotype of these mice. Results The 5-LO protein is upregulated in human tauopathy and transgenic tau mice brains. Pharmacologic blockade of 5-LO in tau mice resulted in significant memory improvement, rescue of synaptic integrity and dysfunction, and reduction of tau pathology via a cdk5-dependent mechanism. Conclusions These results establish a key role of 5-LO in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.org/dc/terms/identifier	"doi:10.1016/j.biopsych.2015.01.015"xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/author	"Chu J."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/author	"Yu W.H."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/author	"Li J.G."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/author	"Pratico D."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/author	"Kirby L.G."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/author	"Sperow M."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/author	"Giannopoulos P.F."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/author	"Abood M."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/date	"2015"xsd:gYear
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/name	"Biol Psychiatry"xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/pages	"693-701"xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/title	"Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy."xsd:string
http://purl.uniprot.org/citations/25802082	http://purl.uniprot.org/core/volume	"78"xsd:string
http://purl.uniprot.org/citations/25802082	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/25802082
http://purl.uniprot.org/citations/25802082	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/25802082
http://purl.uniprot.org/uniprot/#_A0A0A0MQC7-mappedCitation-25802082	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25802082
http://purl.uniprot.org/uniprot/#_E9QA93-mappedCitation-25802082	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25802082
http://purl.uniprot.org/uniprot/#_A0A0N4SW45-mappedCitation-25802082	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25802082
http://purl.uniprot.org/uniprot/#_E9Q6H6-mappedCitation-25802082	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25802082
http://purl.uniprot.org/uniprot/#_A2A5Y6-mappedCitation-25802082	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25802082
http://purl.uniprot.org/uniprot/#_B1AQW2-mappedCitation-25802082	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25802082
http://purl.uniprot.org/uniprot/#_B1AQW4-mappedCitation-25802082	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25802082