| http://purl.uniprot.org/citations/25806796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25806796 | http://www.w3.org/2000/01/rdf-schema#comment | "Locally produced growth hormone (GH) and IGF-I are key factors in the regulation of mammary gland (MG) development and may be important in breast cancer development/progression. Somatostatin (SST) and cortistatin (CORT) regulate GH/IGF-I axis at various levels, but their role in regulating GH/IGF-I in MGs remains unknown. Since obesity alters the expression of these systems in different tissues and is associated to MG (patho) physiology, we sought to investigate the role of SST/CORT in regulating GH/IGF-I system in the MGs of lean and obese mice. Therefore, we analyzed GH/IGF-I as well as SST/CORT and ghrelin systems expression in the mammary fat pads (MFPs) of SST- or CORT-knockout (KO) mice and their respective littermate-controls fed a low-fat (LF) or a high-fat (HF) diet for 16 wks. Our results demonstrate that the majority of the components of GH/IGF-I, SST/CORT and ghrelin systems are locally expressed in mouse MFP. Expression of elements of the GH/IGF-I axis was significantly increased in MFPs of HF-fed control mice while lack of endogenous SST partially suppressed, and lack of CORT completely blunted, the up-regulation observed in obese WT-controls. Since SST/CORT are known to exert an inhibitory role on the GH/IGFI axis, the increase in SST/CORT-receptor sst2 expression in MFPs of HF-fed CORT- and SST-KOs together with an elevation on circulating SST in CORT-KOs could explain the differences observed. These results offer new information on the factors (GH/IGF-I axis) involved in the endocrine/metabolic dysregulation of MFPs in obesity, and suggest that CORT is not a mere SST sibling in regulating MG physiology."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0120955"xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "de Lecea L."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Cordoba-Chacon J."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Castano J.P."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Luque R.M."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Gahete M.D."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Pozo-Salas A.I."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Lopez-Miranda J."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Villa-Osaba A."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Delgado-Lista F.J."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/author | "Alvarez-Benito M."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/pages | "e0120955"xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/title | "Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin."xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/25806796 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25806796 |
| http://purl.uniprot.org/citations/25806796 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25806796 |
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| http://purl.uniprot.org/uniprot/#_P60041-mappedCitation-25806796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25806796 |
| http://purl.uniprot.org/uniprot/#_Q545V6-mappedCitation-25806796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25806796 |
| http://purl.uniprot.org/uniprot/P56469 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25806796 |
| http://purl.uniprot.org/uniprot/P60041 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25806796 |