| http://purl.uniprot.org/citations/25807545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25807545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25807545 | http://www.w3.org/2000/01/rdf-schema#comment | "The oldest extant human maternal lineages include mitochondrial haplogroups L0d and L0k found in the southern African click-speaking forager peoples broadly classified as Khoesan. Profiling these early mitochondrial lineages allows for better understanding of modern human evolution. In this study, we profile 77 new early-diverged complete mitochondrial genomes and sub-classify another 105 L0d/L0k individuals from southern Africa. We use this data to refine basal phylogenetic divergence, coalescence times and Khoesan prehistory. Our results confirm L0d as the earliest diverged lineage (∼172 kya, 95%CI: 149-199 kya), followed by L0k (∼159 kya, 95%CI: 136-183 kya) and a new lineage we name L0g (∼94 kya, 95%CI: 72-116 kya). We identify two new L0d1 subclades we name L0d1d and L0d1c4/L0d1e, and estimate L0d2 and L0d1 divergence at ∼93 kya (95%CI:76-112 kya). We concur the earliest emerging L0d1'2 sublineage L0d1b (∼49 kya, 95%CI:37-58 kya) is widely distributed across southern Africa. Concomitantly, we find the most recent sublineage L0d2a (∼17 kya, 95%CI:10-27 kya) to be equally common. While we agree that lineages L0d1c and L0k1a are restricted to contemporary inland Khoesan populations, our observed predominance of L0d2a and L0d1a in non-Khoesan populations suggests a once independent coastal Khoesan prehistory. The distribution of early-diverged human maternal lineages within contemporary southern Africans suggests a rich history of human existence prior to any archaeological evidence of migration into the region. For the first time, we provide a genetic-based evidence for significant modern human evolution in southern Africa at the time of the Last Glacial Maximum at between ∼21-17 kya, coinciding with the emergence of major lineages L0d1a, L0d2b, L0d2d and L0d2a."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0121223"xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Beeson K."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Beeson K."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Chan E.K."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Chan E.K."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Smith A.B."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Smith A.B."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Bornman R.M."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Bornman R.M."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Hardie R.A."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Hardie R.A."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Hayes V.M."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Hayes V.M."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Petersen D.C."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/author | "Petersen D.C."xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/pages | "E0121223"xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/pages | "e0121223"xsd:string |
| http://purl.uniprot.org/citations/25807545 | http://purl.uniprot.org/core/title | "Revised timeline and distribution of the earliest diverged human maternal lineages in southern Africa."xsd:string |