| http://purl.uniprot.org/citations/25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25809405 | http://www.w3.org/2000/01/rdf-schema#comment | "Tissue expansion and patterning are integral to development; however, it is unknown quantitatively how a mother accumulates molecular resources to invest in the future of instructing robust embryonic patterning. Here we develop a model, Tissue Expansion-Modulated Maternal Morphogen Scaling (TEM(3)S), to study scaled anterior-posterior patterning in Drosophila embryos. Using both ovaries and embryos, we measure a core quantity of the model, the scaling power of the Bicoid (Bcd) morphogen gradient's amplitude nA. We also evaluate directly model-derived predictions about Bcd gradient and patterning properties. Our results show that scaling of the Bcd gradient in the embryo originates from, and is constrained fundamentally by, a dynamic relationship between maternal tissue expansion and bcd gene copy number expansion in the ovary. This delicate connection between the two transitioning stages of a life cycle, stemming from a finite value of nA~3, underscores a key feature of developmental systems depicted by TEM(3)S."xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7679"xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/author | "He F."xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/author | "Wei C."xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/author | "Cheung D."xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/author | "Jiao R."xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/pages | "6679"xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/title | "Fundamental origins and limits for scaling a maternal morphogen gradient."xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25809405 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25809405 |
| http://purl.uniprot.org/citations/25809405 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25809405 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGY5-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |
| http://purl.uniprot.org/uniprot/#_P09081-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |
| http://purl.uniprot.org/uniprot/#_P22977-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |
| http://purl.uniprot.org/uniprot/#_P05084-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |
| http://purl.uniprot.org/uniprot/#_P25724-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |
| http://purl.uniprot.org/uniprot/#_P06602-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |
| http://purl.uniprot.org/uniprot/#_P07184-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |
| http://purl.uniprot.org/uniprot/#_P07185-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |
| http://purl.uniprot.org/uniprot/#_P07186-mappedCitation-25809405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25809405 |