| http://purl.uniprot.org/citations/25814530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25814530 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the B7 family have been shown to be important for regulating immune responses by providing either positive or negative costimulatory signals. The function of B7-H3 has been controversial. We show that B7-H3 is upregulated in graft-versus-host disease (GVHD) target organs, including the colon, liver, and lung. Infusion of allogeneic donor T cells into B7-H3(-/-) vs wild-type (WT) recipients resulted in increased GVHD lethality associated with increased T-cell proliferation, colonic inflammatory cytokines, and destruction of epithelial barriers. Allogeneic B7-H3(-/-) vs WT donor T cells also had increased T-cell proliferation and GVHD lethality associated with increased proliferation and cytokine secretion in the spleen, intraepithelial lymphocyte inflammatory cytokines, and intestinal permeability. Both resting and activated regulatory T cells (Tregs) lack B7-H3 messenger RNA. Consistent with these data, GVHD was augmented in recipients of B7-H3(-/-) Treg-depleted grafts. In two delayed lymphocyte infusion (DLI) models, T cells lacking B7-H3 are capable of providing graft-versus-leukemia (GVL) effects. We conclude that B7-H3 is responsible for providing a negative costimulatory signal. Our studies provide support for developing and testing new therapies directed toward the B7-H3 pathway, including approaches to augment host B7-H3 early after bone marrow transplantation to prevent GVHD and to develop potent antagonistic antibodies later after transplant to facilitate DLI-mediated GVL without GVHD complications."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2014-09-603357"xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Saha A."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Murphy W.J."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Freeman G.J."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Flynn R."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Allison J.P."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Osborn M.J."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Schmitt-Graeff A."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Blazar B.R."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Panoskaltsis-Mortari A."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Kreymborg K."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Munn D.H."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Taylor P.A."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Serody J.S."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Zeiser R."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Veenstra R.G."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "McDonald-Hyman C."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "Lieberknecht E."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/author | "van den Brink M."xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/25814530 | http://purl.uniprot.org/core/pages | "3335-3346"xsd:string |