| http://purl.uniprot.org/citations/25819561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25819561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25819561 | http://www.w3.org/2000/01/rdf-schema#comment | "Caenorhabditis elegans embryos rapidly diversify cell fate using a modified Wnt/β-catenin signaling strategy to carry out serial asymmetric cell divisions (ACDs). Wnt-dependent ACDs rely on nuclear asymmetry of the transcriptional coactivator SYS-1/β-catenin between daughter cells to differentially activate Wnt-responsive target genes. Here, we investigate how dynamic localization of SYS-1 to mitotic centrosomes influences SYS-1 inheritance in daughter cells and cell-fate outcomes after ACD. Through yeast two-hybrid screening, we identify the centrosomal protein RSA-2 as a SYS-1 binding partner and show that localization of SYS-1 to mitotic centrosomes is dependent on RSA-2. Uncoupling SYS-1 from the centrosome by RSA-2 depletion increases SYS-1 inheritance after ACD and promotes Wnt-dependent cell fate. Photobleaching experiments reveal that centrosome-bound SYS-1 turns over rapidly. Interestingly, disruption of the proteasome leads to an increased accumulation of SYS-1 at the centrosome but disrupts its dynamic turnover. We conclude that centrosomal targeting of SYS-1 promotes its degradation during asymmetric cell division. We propose a model whereby centrosome-associated SYS-1 degradation couples negative regulation with cell-division timing to facilitate SYS-1 clearance from the mother cell at the time of asymmetric division. Based on our observations of centrosomal SYS-1 dynamics, we discuss the possibility that the centrosome may coordinate various cell-cycle-dependent processes by synchronizing mitosis and protein regulation."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2015.02.020"xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2015.02.020"xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/author | "Phillips B.T."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/author | "Phillips B.T."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/author | "Vora S."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/author | "Vora S."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/pages | "1005-1016"xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/pages | "1005-1016"xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/title | "Centrosome-associated degradation limits beta-catenin inheritance by daughter cells after asymmetric division."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/title | "Centrosome-associated degradation limits beta-catenin inheritance by daughter cells after asymmetric division."xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/25819561 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25819561 |
| http://purl.uniprot.org/citations/25819561 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25819561 |
| http://purl.uniprot.org/citations/25819561 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25819561 |
| http://purl.uniprot.org/citations/25819561 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25819561 |
| http://purl.uniprot.org/uniprot/G5EFV3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/25819561 |
| http://purl.uniprot.org/uniprot/Q10666#attribution-436DA45614A8F7FE826D41A0FA65C7BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25819561 |