| http://purl.uniprot.org/citations/25822952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25822952 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic initiation factor (eIF) 4E-binding proteins (4E-BPs) are translational repressors that bind specifically to eIF4E and are critical in the control of protein translation. 4E-BP2 is the predominant 4E-BP expressed in the brain, but their role is not well known. Here, we characterized four forms of 4E-BP2 detected by two-dimensional gel electrophoresis (2-DGE) in brain. The form with highest electrophoretic mobility was the main form susceptible to phosphorylation at Thr37/Thr46 sites, phosphorylation that was detected in acidic spots. Cerebral ischemia and subsequent reperfusion induced dephosphorylation and phosphorylation of 4E-BP2 at Thr37/Thr46, respectively. The induced phosphorylation was in parallel with the release of 4E-BP2 from eIF4E, although two of the phosphorylated 4E-BP2 forms were bound to eIF4E. Upon long-term reperfusion, there was a decrease in the binding of 4E-BP2 to eIF4E in cerebral cortex, demonstrated by cap binding assays and 4E-BP2-immunoprecipitation experiments. The release of 4E-BP2 from eIF4E was without changes in 4E-BP2 phosphorylation or other post-translational modification recognized by 2-DGE. These findings demonstrated specific changes in 4E-BP2/eIF4E association dependent and independent of 4E-BP2 phosphorylation. The last result supports the notion that phosphorylation may not be the uniquely regulation for the binding of 4E-BP2 to eIF4E under ischemic stress."xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0121958"xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/author | "Alcazar A."xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/author | "Salvador N."xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/author | "Martinez-Alonso E."xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/author | "Regidor I."xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/author | "Ayuso M.I."xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/author | "Bonova P."xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/pages | "e0121958"xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/title | "Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response."xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/25822952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25822952 |
| http://purl.uniprot.org/citations/25822952 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25822952 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K113-mappedCitation-25822952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25822952 |
| http://purl.uniprot.org/uniprot/#_A6K3Z8-mappedCitation-25822952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25822952 |
| http://purl.uniprot.org/uniprot/#_Q13542-mappedCitation-25822952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25822952 |
| http://purl.uniprot.org/uniprot/#_Q497A9-mappedCitation-25822952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25822952 |
| http://purl.uniprot.org/uniprot/Q13542 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25822952 |
| http://purl.uniprot.org/uniprot/A6K3Z8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25822952 |
| http://purl.uniprot.org/uniprot/A0A0G2K113 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25822952 |
| http://purl.uniprot.org/uniprot/Q497A9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25822952 |