| http://purl.uniprot.org/citations/25823027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25823027 | http://www.w3.org/2000/01/rdf-schema#comment | "Whole-genome and transcriptome sequencing were used to discover novel gene fusions in a case of colon cancer. A tumor-specific LACTB2-NCOA2 fusion originating from intra-chromosomal rearrangement of chromosome 8 was identified at both DNA and RNA levels. Unlike conventional oncogenic chimeric proteins, the fusion product lacks functional domain from respective genes, indicative of an amorphic rearrangement. This chimeric LACTB2-NCOA2 transcript was detected in 6 out of 99 (6.1%) colorectal cancer (CRC) cases, where NCOA2 was significantly downregulated. Enforced expression of wild-type NCOA2 but not the LACTB2-NCOA2 fusion protein impaired the pro-tumorigenic phenotypes of CRC cells, whereas knockdown of endogenous NCOA2 in normal colonocytes had opposite effects. Mechanistically, NCOA2 inhibited Wnt/β-catenin signaling through simultaneously upregulating inhibitors and downregulating stimulators of Wnt/β-catenin pathway. Collectively, our data supports that NCOA2 is a novel negative growth regulatory gene repressing the Wnt/β-catenin pathway in CRC, where recurrent fusion with LACTB2 contributes to its disruption."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2015.72"xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "He J."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Liang Q."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Sung J.J."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Zhang N."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Ng S.S."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Chan M.T."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/author | "Wu W.K."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/pages | "187-195"xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/title | "Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/25823027 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25823027 |
| http://purl.uniprot.org/citations/25823027 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25823027 |
| http://purl.uniprot.org/uniprot/#_A0A024R811-mappedCitation-25823027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25823027 |
| http://purl.uniprot.org/uniprot/#_Q15596-mappedCitation-25823027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25823027 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XJZ8-mappedCitation-25823027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25823027 |
| http://purl.uniprot.org/uniprot/#_A3FFT2-mappedCitation-25823027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25823027 |