| http://purl.uniprot.org/citations/25824639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25824639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25824639 | http://www.w3.org/2000/01/rdf-schema#comment | "The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). How borrelidin simultaneously attenuates bacterial growth and suppresses a variety of infections in plants and animals is not known. Here we show, using X-ray crystal structures and functional analyses, that a single molecule of borrelidin simultaneously occupies four distinct subsites within the catalytic domain of bacterial and human ThrRSs. These include the three substrate-binding sites for amino acid, ATP and tRNA associated with aminoacylation, and a fourth 'orthogonal' subsite created as a consequence of binding. Thus, borrelidin competes with all three aminoacylation substrates, providing a potent and redundant mechanism to inhibit ThrRS during protein synthesis. These results highlight a surprising natural design to achieve the quadrivalent inhibition of translation through a highly conserved family of enzymes."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7402"xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7402"xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Guo M."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Guo M."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Francklyn C.S."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Francklyn C.S."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Fang P."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Fang P."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Jeong S.J."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Jeong S.J."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Mirando A."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/author | "Mirando A."xsd:string |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25824639 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |