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http://purl.uniprot.org/citations/25825846http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Context

Inflammation plays a critical role in the development and progression of obstructive sleep apnea (OSA). Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) activation is involved in the pathophysiology of inflammatory process-related disorders.

Objective

This study aims to investigate whether serum soluble LOX-1 (sLOX-1) levels are associated with the presence and severity of OSA.

Materials and methods

A total of 137 OSA patients and 78 controls were recruited in this study. Serum sLOX-1 levels were measured by enzyme-linked immunosorbent assay. The severity of OSA was assessed by the apnea-hypopnea index (AHI).

Results

OSA patients had significantly higher serum sLOX-1 levels compared with controls. Serum sLOX-1 levels elevated with the increment of OSA severity. sLOX-1 was the independent predictor of OSA. Serum sLOX-1 levels were significantly correlated with AHI and high-sensitivity C-reactive protein levels.

Conclusions

Serum sLOX-1 levels were independently correlated with the presence and severity of OSA. These findings revealed that sLOX-1 might function as a potential biomarker for monitoring the development and progression of OSA."xsd:string
http://purl.uniprot.org/citations/25825846http://purl.org/dc/terms/identifier"doi:10.1089/gtmb.2015.0027"xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/author"Xu C.Y."xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/author"Lou H.J."xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/author"Wu C.L."xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/author"Jiang H.W."xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/author"Li D.J."xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/author"Ding G.Q."xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/name"Genet Test Mol Biomarkers"xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/pages"272-276"xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/title"Serum sLOX-1 Levels Are Correlated with the Presence and Severity of Obstructive Sleep Apnea."xsd:string
http://purl.uniprot.org/citations/25825846http://purl.uniprot.org/core/volume"19"xsd:string
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