| http://purl.uniprot.org/citations/25829232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25829232 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic and environmental factors contribute to the onset and progression of lupus. CD4+ T cells from patients with active lupus show a decreased ERK signaling pathway, which causes changes in gene expression. The defect points to its upstream regulator, PKCδ, which exhibits a deficient activity due to oxidative stress. Our aim was to investigate the effect of a defective PKCδ in the development of lupus. We generated a double transgenic C57BL6 × SJL mouse that expresses a doxycycline-induced dominant negative PKCδ (dnPKCδ) in T cells. The transgenic mice displayed decreased T cell ERK signaling, decreased DNMT1 expression and overexpression of methylation sensitive genes involved in the exaggerated immune response in the pathogenesis of lupus. The mice developed anti-dsDNA autoantibodies and glomerulonephritis with IgG deposition. The study indicates common pathogenic mechanisms with human lupus, suggesting that environmentally-mediated T cell PKCδ inactivation plays a causative role in lupus."xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.clim.2015.03.017"xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/author | "Patel D."xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/author | "Johnson K."xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/author | "Richardson B."xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/author | "Gorelik G."xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/author | "Sawalha A.H."xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/name | "Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/pages | "193-203"xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/title | "T cell PKCdelta kinase inactivation induces lupus-like autoimmunity in mice."xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://purl.uniprot.org/core/volume | "158"xsd:string |
| http://purl.uniprot.org/citations/25829232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25829232 |
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