| http://purl.uniprot.org/citations/25829452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25829452 | http://www.w3.org/2000/01/rdf-schema#comment | "Intestine contributes to energy homeostasis through the absorption, metabolism, and transfer of nutrients to the organism. We demonstrated previously that hepatocyte nuclear receptor-4α (HNF-4α) controls intestinal epithelium homeostasis and intestinal absorption of dietary lipids. HNF-4γ, the other HNF-4 form highly expressed in intestine, is much less studied. In HNF-4γ knockout mice, we detect an exaggerated insulin peak and improvement in glucose tolerance during oral but not intraperitoneal glucose tolerance tests, highlighting the involvement of intestine. Moreover, the enteroendocrine L-type cell lineage is modified, as assessed by the increased expression of transcription factors Isl1, Foxa1/2, and Hnf4a, leading to an increase of both GLP-1-positive cell number and basal and stimulated GLP-1 plasma levels potentiating the glucose-stimulated insulin secretion. Using the GLP-1 antagonist exendin (9-39), we demonstrate a direct effect of GLP-1 on improved glucose tolerance. GLP-1 exerts a trophic effect on pancreatic β-cells, and we report an increase of the β-cell fraction correlated with an augmented number of proliferative islet cells and with resistance to streptozotocin-induced diabetes. In conclusion, the loss of HNF-4γ improves glucose homeostasis through a modulation of the enteroendocrine cell lineage."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.org/dc/terms/identifier | "doi:10.2337/db14-0993"xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Rousset M."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Ribeiro A."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Lacasa M."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Guillemain G."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Cardot P."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Carriere V."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Serradas P."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Garbin K."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Blondeau B."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Baraille F."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Ayari S."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/author | "Osinski C."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/pages | "2744-2756"xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/title | "Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4gamma: A Critical Role for Enteroendocrine Cell Lineage."xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/25829452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25829452 |
| http://purl.uniprot.org/citations/25829452 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25829452 |
| http://purl.uniprot.org/uniprot/#_A2ICG8-mappedCitation-25829452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25829452 |
| http://purl.uniprot.org/uniprot/#_A2A5I6-mappedCitation-25829452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25829452 |
| http://purl.uniprot.org/uniprot/#_A2A5I4-mappedCitation-25829452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25829452 |