| http://purl.uniprot.org/citations/2583099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2583099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2583099 | http://www.w3.org/2000/01/rdf-schema#comment | "Two forms of plasminogen activators inhibitor 2 (PAI-2) are synthesized by human and murine monocytes/macrophages: one accumulates in the cytosol, while the other is translocated into the endoplasmic reticulum, glycosylated and secreted. We show here that a single mRNA encodes both forms of PAI-2. Firstly, a single PIA-2 mRNA was detected by Northern blot hybridization and by RNase protection. Secondly, transfection of a PAI-2 cDNA led to the synthesis of both forms of PAI-2. Finally, in vitro translation of an mRNA transcript of the PAI-2 cDNA in the presence of microsomal membranes generated two topologically distinct forms of PAI-2. The cytosolic and secreted forms of PAI-2 do not result from the use of two translation start sites, since their synthesis initiates at the same AUG, in a sequence context that is conserved between the human and murine genes. Thus, the accumulation of one polypeptide into two topologically distinct cellular compartments can be achieved by facultative translocation."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1989.tb08489.x"xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1989.tb08489.x"xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Belin D."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Belin D."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Vassalli J.-D."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Vassalli J.-D."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Kruithof E.K.O."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Kruithof E.K.O."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Wohlwend A."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Wohlwend A."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Schleuning W.-D."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/author | "Schleuning W.-D."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/pages | "3287-3294"xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/pages | "3287-3294"xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/title | "Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/title | "Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2."xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/2583099 | http://purl.uniprot.org/core/volume | "8"xsd:string |