| http://purl.uniprot.org/citations/25832561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25832561 | http://www.w3.org/2000/01/rdf-schema#comment | "Glioblastomas, the most aggressive form of primary brain tumors with a tendency to invade surrounding healthy brain tissues, remains an incurable disease. Intersectin (ITSN) is a multidomain adapter protein implicated in endocytosis, exocytosis, and multiple signaling pathways. Prior research of ours has shown intersectin1-S (ITSN1-S) is critical for the migration and invasion of glioma cells by regulating several key proteins. In this study, we established ITSN1-S expression patterns in human tumor tissues. We discovered that ITSN1-S expression was positively correlated with histological grade of gliomas and with poor patient prognosis. We also found that the expression of ITSN1-S protein was essential to glioblastoma cell proliferation. Furthermore, through a series of expression constructs encoding different ITSN1-S domains, we identified the critical roles of ITSN1-S SH3 domains in the regulation of cell proliferation. This study also demonstrates evidence suggesting that the regulation of ITSN1-S on glioblastoma cells proliferation is through the Raf/MEK/ERK pathway. In conclusion, this study suggests critical roles of ITSN1-S in malignant glioma proliferation, indicating a potential usage of ITSN1-S in the therapeutic intervention as a novel molecular target."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.org/dc/terms/identifier | "doi:10.1002/glia.22830"xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Fu L."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Ying G."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Qin F."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/author | "Gu F."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/name | "Glia"xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/pages | "1595-1605"xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/title | "Intersectin1-S, a multidomain adapter protein, is essential for malignant glioma proliferation."xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/25832561 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25832561 |
| http://purl.uniprot.org/citations/25832561 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25832561 |
| http://purl.uniprot.org/uniprot/#_A7XZY7-mappedCitation-25832561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832561 |
| http://purl.uniprot.org/uniprot/#_A0A2X0TVY8-mappedCitation-25832561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832561 |
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| http://purl.uniprot.org/uniprot/#_A8W608-mappedCitation-25832561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832561 |
| http://purl.uniprot.org/uniprot/#_D6PAV9-mappedCitation-25832561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832561 |